What is Neurotherapy?

The subcutaneous injection of dilute (5%) dextrose to turn off a complex array of specific sensory nerves (TRPV-1) that when stimulated produce certain proteins (Substance P & CGRP) that irritate pain nerves (C-fiber) that become swollen and painful.  The dilute dextrose binds to these receptors and prevents the release of these proteins and turns off these neuropathic receptors.  These receptors are found throughout the body, and the highest concentrations are found around joints, tendons and ligaments.  Neurotherapy does NOT induce or initiate the AA inflammatory cascade.  This is why NSAID’s (ie: Advil, Naprosyn, etc.) are not effective on this type of pain.

Why is it different than Prolotherapy?

Prolotherapy is the deeper injection of irritant solutions (typically 15-25% dextrose, but other solutions are often used) into weakened or diseased ligaments or tendons which are felt to be the source of chronic pain, that promotes a healing response of these tissues through activation of the AA inflammatory cascade.


It is extremely safe (as the injection is subcutaneous), the pain relief can be dramatic, there are no steroids, it does NOT induce an AA inflammatory reaction, it can help restore the nutrient pathways to deeper nerves which can result in long-term pain relief.


It is an injection.  The therapy tends to be less effective in smokers and diabetic patients.

Where can this therapy used?

Almost any musculoskeletal pain/chronic pain problem!!

What should I expect?

A very short time of mild to moderate discomfort at the time of the injection.  The response may last a few hours to a few weeks.

Response to the therapy is determined by improvement in pain and function.  The therapy is coordinated with a good strength and conditioning program and proper nutrition is recommended.  Repeat treatments are usually done at 1-2 week intervals as necessary.

Should you have any additional questions, please do not hesitate to contact our office.  We will be more than happy to answer any questions you may have.  (503) 691-2000