STEMCELL THERAPIES OVERVIEW

Are you tired of the same ineffective medical or surgical treatments that just don’t seem to be working very well?  Einstein said that the definition of futility or insanity is “doing the same thing over and over again and expecting a different result.”-Albert Einstein

“Neuromuscular and Musculoskeletal pain” is the most common and debilitating conditions that affect people of all walks of life.  It is the most common reason for physician visits and is one of the problems that results in the most work days lost in the United States.   This results in significant time loss, functional limitations, and if left untreated or undiagnosed, can result in long-term problems.   Most of us have experienced some form of musculoskeletal pain or injuries in our lives, and often times these problems are chronic and limiting, impacting your daily life.  Often times the traditional treatments such as medications, physical therapy, injections and even surgery have only resulted in limited or minimal long-term improvements.

There are many other injuries and conditions that do not show any outward or visible signs but are just as debilitating as any traumatic structural injury such as concussions, PTSD, strokes, autoimmune diseases, migraine headaches, etc.  These types of conditions have been notoriously difficult to treat, and often times just trying to managing them, are difficult and ineffective at best.  If you have tried a variety of therapies and nothing has seemed to work, maybe it is time to think outside the box and consider a therapy that may help unlock your body’s own ability to heal and to help restore your health.

Congratulations!  You have chosen to look at your problem/condition in a different way and hopefully get a better result.  Stem cell derived growth factors called ‘exosomes,’ is a new regenerative treatment therapy that in my opinion is one of THE most exciting treatment options that is currently available anywhere.  Not only do I think this is an incredible new treatment tool, I feel it may change how we are able to treat patients and problems that previously have been inadequately treated or were even thought to be untreatable.

Note: not all conditions may resolve with these regenerative non-surgical therapies and some conditions may ultimately require other interventions.  This provides you with another therapy option to consider that previously was not available.

‘STEMCELL’ therapy or the more correct terminology is ‘REGENERATIVE’ therapies are new and promising therapies which utilizes cutting edge technologies to concentrating and purifying the body’s natural healing abilities.  These are the body’s bioactive (Pleuripotent) cells, which have the ability to repair connective tissues (ie: bone, ligament, tendon, cartilage, muscle, nerve, etc) and not to be confused with ‘embryonic stem’ cells.  These incredible bioactive cells significantly enhance the natural healing ability, and are being utilized in Orthopedics, anti-aging, cosmetics, sexual dysfunction, Alzheimer’s, neurologic issues, just to name a few of the conditions currently being studied and treated, with some amazing results.

Most people are familiar with ‘PRP’ – Platelet Rich Plasma therapies.  This therapy has been used in a variety of musculoskeletal injuries and in cosmetics, the so called ‘Vampire Face Lift’, is a treatment that utilizes PRP technology.  But ‘REGENERATIVE’ therapies is so much more than just PRP.  It utilizes a variety of cellular and regenerative components to help speed healing and improve function.  These types of treatments can be used in conjunction with surgery or as the primary treatment option.

THESE THERAPIES INCLUDE:

EXOSOMES: Exosomes are acellular neonatal stem cell derived growth factors safely obtained from neonatal placental tissues that are safely bioengineered and processed.  These stem cell derived growth factors contain a variety of proteins, miRNA, mRNA, and various factors that can be actively transported from cell to cell.  These nanoparticles that contain growth factors and mRNA, have the amazing ability to promote healing by “blue printing” and producing proteins and other molecules that promote other cells to migrate to the area (paracrine effect), that promotes healing, anti-inflammatory effects, stimulates cellular regeneration, stem cell production and activity.  This maximizes these beneficial and healing effects which may last several months instead of several days as is typically the case with traditional and other current regenerative stem cell therapies.

PRP/PRF (platelet rich plasma/platelet rich fibrin): concentrated cellular components that contain a variety of growth and healing signaling factors, it is excellent initial therapy for any musculoskeletal injury or problem.

A2M (alpha-2-macroglobulin): a protein molecule found in your blood plasma, it helps stop or slow the progression of degenerative arthritis in joints, often used as a pre-treatment.

PLACENTAL-AMNIOTIC MATRIX: concentrated growth factors that are obtained from healthy donors.  More concentrated that PRP and can be used for the same problems.

BMAC (bone marrow aspirate concentrate): this is where our body produces the stromal and vascular cell types.  Typically used in bone and joint problems, as well as most other regenerative treatments.  Can be used as a primary therapy, but if often used in conjunction with other regenerative therapies.

ADIPOSE (fat) cells: which typically have the highest concentration of stromal fraction.  This type of therapy is often used in cosmetics and when the more traditional PRP and growth factor treatments are not effective enough.

WHAT ARE EXOSOMES?

What are exosomes?  Exosomes are acellular neonatal stem cell derived growth factors safely obtained from neonatal placental tissues that are safely bioengineered and processed.  These stem cell derived growth factors contain a variety of proteins, miRNA, mRNA, and various factors that can be actively transported from cell to cell.  These nanoparticles that contain growth factors and mRNA, have the amazing ability to promote healing by “blue printing” and producing proteins and other molecules that promote other cells to migrate to the area (paracrine effect), that promotes healing, anti-inflammatory effects, stimulates cellular regeneration, stem cell production and activity.  This maximizes these beneficial and healing effects which may last several months instead of several days as is typically the case with traditional and other current regenerative stem cell therapies.

HOW DO EXOSOME WORK? (they upregulates your own resident progenitor/stem cells):

  • Angiogenesis, Neurogenesis, Osteogenesis, Musculogenesis
  • Increase ratio of collagen III to collagen I
  • Prevent fibroblast differentiation into myofibroblasts
  • Inhibit granulation tissue formation
  • Increase ratio of TGF-B3 to TGF-B2
  • After IV administration, they accumulate in the wound area
  • Increase ratio of MMP3 to TIMP1

ADVANTAGES:

  • nanoparticle
  • stimulates growth of target cells, stem cells
  • promote regeneration
  • Anti-inflammatory
  • promotes scar-less repair
  • anti-fibrotic (inhibits granulation tissue production-ie: scar tissue)
  • Maximize healing and repair of connective tissue
  • Drug free
  • Crosses blood-brain barrier
  • A safe alternative to steroid injections and surgery

MANY KEY GROWTH FACTORS in EXOSOMES:

BMP-5: Stimulates bone growth, GDF-15: growth differentiation factor 15, OPG: stimulates bone growth/blocks osteoclast precursor formation, G-CSF: granulocyte colony stimulating factor, SCF: stem cell factor (responsible for stem cell and melanocyte growth), TGF B3: the most important anti-inflammatory protein.  Converts inflammatory T-cells into anti-inflammatory regulatory T-cells, VEGF: vascular endothelial growth factor, ICAM-1: binds inflammatory ligands on WBC’s, IL-1ra: binds and sequesters the inflammatory cytokine IL-1, IL-6: responsible for macrophage activation, IL-10: anti-inflammatory cytokine responsible for immunomodulation and regulatory T-cell conversion’ MCP-1: monocyte chemoattractant protein-1 is a chemokine that recruits mononuclear cells to treatment area, MIP-1: (aka: CCL-42) is a chemokine that recruits mononuclear cells to the target area, PDGF-bb: platelet derived growth factor beta, TIMP-1, TIMP-2: tissue inhibitor of matrix metalloproteinase, block collagen and extracellular matrix degradation. *Important in cartilage repair, TNF-RI: binds and inactivates the inflammatory TNF-a

IMMUNOLOGICAL EFFECTS: (immunomodulation without immunosuppression)

  • Downregulates TH1 and TH17, while upregulating T-reg cells
  • Upregulates M2 macrophages at the expense of M1 macrophages

NOTIFY US IF HAVE or MAY HAVE ANY OF THESE:

if you have any active cancers, active bacterial infections, recent dental work (within the last 3 months), any type of neovascularization, any myeloproliferative diseases (sickle cell, bone marrow dysplasia), immune compromised conditions, primary pulmonary hypertension, macular degeneration with neovascularization.

GENERAL INFORMATION:

  • Typically your activity will be easy and careful for the first 6 weeks, then carefully increase your activity over the next 6-12 weeks, and then advance your activity as tolerated after 12 weeks following treatment.
  • Reassessments at 4, 8, 12 weeks to assess response, retreatments, etc.

PRECAUTIONS:

  • Before any treatment: you will stop all NSAID’s (except baby aspirin) a minimum of 7 days before your treatment, and you will NOT take any more NSAID’s for 3 months after your treatment.
  • If you are going to have a spinal procedure, you will need to stop any blood thinners and/or will need to be changed to a temporary blood thinner that can be temporarily and safely stopped at the time of your procedure.
  • Pretreat with 25-50mg bendaryl + 1g acetaminophen orally 1 hour before if there is a concern for possible flushing, sensitivity, etc (if you are on Humera or other immune modulator).
  • Notify us if you are or could be pregnant.

What does all this really mean for you?  This means that the chronic painful inflammatory processes that perpetuate inflammation, scar tissue, and most importantly chronic painful states, can now be treated to help reverse these painful processes, allow for more normal healing and function, and most importantly decrease your pain and dramatically improve your function!

WHAT CAN IT TREAT?

Concussions, traumatic brain and cord injuries, systemic inflammatory problems, joint and other musculoskeletal injuries or problems, chronic painful conditions, disc and other spine problems, autism, hair restoration, sexual dysfunctions in both men and women, bladder incontinence, etc….  an incredible treatment tool that almost sounds too good to be true!


If you think that surgery maybe your only option, or have not had the type of results with more traditional treatments, or just have questions, please consider regenerative therapies as a better option.

If you think that surgery maybe your only option, or have not had the type of results with more traditional treatments, or just have questions, please consider regenerative therapies as a better option.

Please contact our office to see if one of these regenerative therapy options may be right for you.

Please contact our office at 503 691-2000, website: www.huebetssc.com, or email us: ma@huebertssc.com